Trimethylaluminium mediated amide bond formation in a continuous flow microreactor as key to the synthesis of rimonabant and efaproxiral.
نویسندگان
چکیده
A safe, functional-group-tolerant and high-throughput version of the trimethylaluminium mediated amide bond formation reaction has been developed in a microreactor system; rimonabant and efaproxiral were prepared to illustrate the utility of the method.
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ورودعنوان ژورنال:
- Chemical communications
دوره 9 شماره
صفحات -
تاریخ انتشار 2008